Most people think of T1D in the final chronic stage, where patients are hyperglycemic and insulin dependent. But prior to this, there is a period in which the disease is present and detectable, but typically develops undiagnosed.1
A blood test can detect autoantibodies and diagnose T1D before clinical disease arises.1
Once a patient develops 2 or more autoantibodies, their lifetime risk of clinical T1D approaches 100%.1
Even with advanced tools such as continuous glucose monitoring, many T1D patients are poorly controlled5
Adherence to insulin therapy remains a challenge, especially for young patients, and studies have shown a significant drop in glycemic control as young patients transition to adolescence.10
There is substantial opportunity to improve upon the standard of care, which leaves many patients’ diabetes uncontrolled.
1. Insel RA, Dunne JL, Atkinson MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care. 2015;38(10):1964-1974. 2. LabCorp. Diabetes autoimmune profile. https://www.labcorp.com/tests/504050/diabetes-autoimmune-profile. Accessed August 17, 2020. 3. Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA. 2013;309(23):2473-2479. 4. Writing Committee for Type 1 Diabetes TrialNet Oral Insulin Study Group; Krischer JP, Schatz DA, Bundy B, Skyler JS, Greenbaum CJ. Effect of oral insulin on prevention of diabetes in relatives of patients with type 1 diabetes: a randomized clinical trial. JAMA. 2017;318(19):1891-1902. 5. Foster NC, Beck RW, Miller KM, et al. State of type 1 diabetes management and outcomes from the T1D Exchange in 2016-2018. Diabetes Technol Ther. 2019;21(2):66-72. 6. Quianzon CC, Cheikh I. History of insulin. J Community Hosp Intern Med Perspect. 2012;2(2). 7. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014;383(9911):69-82. 8. American Diabetes Association. Understanding A1C. https://www.diabetes.org/a1c. Accessed August 31, 2020. 9. DiMeglio LA, Acerini CL, Codner E, et al. ISPAD clinical practice consensus guidelines 2018: glycemic control targets and glucose monitoring for children, adolescents, and young adults with diabetes. Pediatr Diabetes. 2018;19(suppl 27):105-114. 10. Datye KA, Moore DJ, Russell WE, Jaser SS. A review of adolescent adherence in type 1 diabetes and the untapped potential of diabetes providers to improve outcomes. Curr Diab Rep. 2015;15(8):51.